KPV (4mg)

KPV is a tripeptide (Lys-Pro-Val) representing the C-terminal sequence of alpha-melanocyte-stimulating hormone that exerts potent anti-inflammatory effects through active transport into cells via the PepT1 transporter, where it inhibits NF-κB and MAPK activation to reduce secretion of inflammatory cytokines. With a molecular weight of 342.43 g/mol, it significantly reduces inflammatory infiltrates and histological signs of colitis in IBD models, with nanoparticle delivery systems enhancing targeted delivery to inflamed colon tissues. It accelerates corneal epithelial wound healing potentially through nitric oxide signaling pathways, and reduces chronic inflammation driving hypertrophic scarring without the pigmentation side effects associated with α-MSH.