GHRP-2 (Pralmorelin) is a synthetic pentapeptide that functions as a potent ghrelin receptor agonist, binding to Growth Hormone Secretagogue Receptors (GHS-Rs) in the pituitary and hypothalamus to trigger a substantial, pulsatile release of growth hormone (GH) from anterior pituitary cells, up to 181-fold in some studies. With a molecular weight of 817.9 g/mol, its research applications include promoting muscle growth by stimulating protein synthesis and suppressing atrophy-related proteins like atrogin-1 and MuRF1. It also demonstrates cardioprotective potential by minimizing cardiac cell apoptosis and oxidative stress, increases deep sleep and REM sleep duration, stimulates appetite via Neuropeptide Y (NPY) and Agouti-related peptide (AgRP), and shows promise in rejuvenating thymic function.


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