Tesamorelin is a synthetic, full-length (44-amino-acid) analog of Growth Hormone-Releasing Hormone (GHRH) with a trans-3-hexenoic acid group added to the N-terminus for enhanced stability, preserving its ability to stimulate natural, pulsatile GH release. With a molecular weight of 5136 g/mol, it demonstrates potent GH-releasing capacity with a 69% increase in total GH levels and 122% surge in IGF-1, making it a primary tool for studying GH deficiency and HIV-associated lipodystrophy where it reduces visceral adiposity by up to 25%. It shows promise in neuroprotection by increasing GABA in dementia models, promotes muscle anabolism by improving muscle tissue density, and reduces liver fat by up to 37%, slowing fibrosis progression.


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