Pentapeptide-18 (Leuphasyl) (200mg)

Pentapeptide-18 (Leuphasyl) is a synthetic analog of the opioid peptide leu-enkephalin that modulates neuromuscular signaling by inhibiting acetylcholine release at the neuromuscular junction through modulation of calcium influx, while also decreasing release of the excitatory neurotransmitter glutamate. With a molecular weight of 569.65 g/mol, it effectively reduces expression wrinkle formation and depth through topical application, showing significant reduction in frontal and periorbital wrinkle trajectory with enhanced efficacy when combined with Argireline through complementary mechanisms. Modified versions with D-tyrosine show anti-melanogenic properties by reducing melanin production in melanoma cells, and its skin penetration makes it valuable for non-invasive muscle relaxation research.