N-Acetyl Semax is a modified, acetylated form of the nootropic peptide Semax consisting of an ACTH fragment fused to a Pro-Gly-Pro tail, with acetylation increasing resistance to enzymatic degradation and the PGP sequence enhancing blood-brain barrier penetration. With a molecular weight of 858.97 g/mol, it upregulates BDNF and activates trkB receptors in the hippocampus to promote neuroplasticity and cognitive function, showing significant improvements in memory recall and attention while increasing BDNF levels in ischemic stroke models for improved functional recovery. It modulates neurotransmitter systems by increasing serotonin metabolism, influences dopamine responsiveness for mood enhancement, inhibits enkephalin-degrading enzymes for pain perception effects, and accelerates gastric ulcer healing in gastroenterology research.



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