Follistatin-344 (1mg)

Follistatin-344 is a synthetic full-length version of the naturally occurring activin-binding protein that acts as a high-affinity binding protein for TGF-β superfamily members, most notably myostatin and activin A, neutralizing their negative regulation of muscle growth. With a molecular weight of 3780 g/mol, its administration leads to dramatic increases in muscle mass through both hypertrophy and hyperplasia, making it a key research tool for studying muscle-wasting diseases like Duchenne Muscular Dystrophy. By suppressing activin A, it reduces inflammation and fibrosis, increases pancreatic beta-cell mass in diabetes research to enhance insulin production, and shows complex roles in oncology by preventing breast cancer metastasis while having varying prognostic associations in different tumor types.