B7-33 (6mg)

B7-33 is a synthetic single-chain peptide derived from H2-relaxin that acts as a functionally selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1), preferentially stimulating the pERK1/2 pathway over the cAMP pathway which is crucial for anti-fibrotic properties. With a molecular weight of 1257.3 g/mol, it stimulates matrix metalloproteinase-2 production in fibroblasts to degrade excess collagen in fibrotic tissues, significantly reducing scarring in models of cardiac fibrosis and chronic allergic asthma. It enhances bradykinin-mediated endothelium-dependent relaxation, protects cytotrophoblast function in preeclampsia models by promoting VEGF production, and is ideal for developing anti-fibrotic coatings for medical implants to reduce fibrotic capsule formation.