ACE-031 (1mg)

ACE-031 is a soluble fusion protein (Ramatercept) composed of the extracellular domain of human activin receptor type IIB fused to the Fc domain of human IgG1, acting as a potent inhibitor of the myostatin pathway by binding and neutralizing myostatin and activin A. With a molecular weight of 3780 g/mol, it demonstrates potent anabolic effects with significant increases in lean body mass and muscle volume, improving maximum contractile force by up to 50% in experimental models. In muscle-wasting disorder models like DMD, it preserves muscle function and increases lean mass, while its inhibition of the activin pathway contributes to improved bone health with 30% increases in bone mass.