Pal-GHK is a synthetic lipopeptide composed of the glycine-histidine-lysine tripeptide conjugated to a palmitic acid chain, engineered for enhanced stability and penetration to deliver the natural collagen fragment signal to fibroblasts. With a molecular weight of 578.8 g/mol, it stimulates fibroblasts to significantly upregulate synthesis of collagen types I, III, IV, elastin, and glycosaminoglycans, increasing skin thickness and elasticity while reducing wrinkles in photodamaged skin models. It neutralizes harmful reactive carbonyl and oxygen species to protect ECM from degradation, accelerates wound closure by enhancing fibroblast activity and neovascularization, and reduces infection rates while modulating inflammatory response.



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