Kisspeptin-10 (Kp-10) is a potent 10-amino-acid peptide fragment derived from Kisspeptin-54 that represents the minimal sequence required for full activation of the KISS1 receptor (GPR54), leading to depolarization of hypothalamic GnRH neurons and potent, pulsatile release of GnRH. With a molecular weight of 1302.4 g/mol, it is a master regulator of the hypothalamic-pituitary-gonadal axis, inducing robust LH and FSH release for studying reproductive function and disorders. It influences energy metabolism by regulating genes for appetite-controlling neuropeptides, shows tumor suppressor activity in metastatic cancers, exhibits neuroprotective properties by mitigating α-synuclein toxicity, and regulates kidney function and vascular tone.



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