ARA-290 (16mg)

ARA-290 is an 11-amino-acid peptide derived from the beta-helix domain of erythropoietin, specifically engineered to activate the innate repair receptor (IRR) without stimulating red blood cell production, initiating anti-inflammatory, anti-apoptotic, and tissue-protective signaling cascades. With a molecular weight of 1257.3 g/mol, it preserves the blood-retinal barrier in retinal ischemia models, inhibits macrophage activation and suppresses pro-inflammatory cytokines, and enhances survival of transplanted islet cells by dampening host immune response. It also exhibits significant pain-mitigating effects by inhibiting TRPV1 channel activity and reduces autoantibody levels in SLE models, positioning it as a key research compound for neuropathic pain, autoimmune disease, and ischemic injury.