Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) analog of the immunomodulatory peptide Tuftsin, engineered with a Pro-Gly-Pro C-terminal sequence to enhance metabolic stability and facilitate blood-brain barrier passage. With a molecular weight of 751.88 g/mol, it acts as an allosteric modulator of GABAA receptors to enhance GABA’s inhibitory effects, underpinning its potent anxiolytic properties while also stabilizing enkephalins by inhibiting their degradation. It modulates the immune system by inhibiting IL-6 production, improves memory traceability independent of anxiolytic effects, positively influences lipid metabolism by reducing cholesterol and fat levels, and enhances serotonin metabolism in the brainstem for mood regulation.



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