FOXO4-DRI

FOXO4-DRI is a synthetic retro-inverso peptide that mimics a fragment of the FOXO4 protein with D-amino acid substitutions for enhanced stability. It selectively targets senescent cells by disrupting FOXO4-p53 binding, restoring p53’s apoptotic function. Research indicates applications in aging, cardiovascular function, insulin signaling, oxidative stress, and hypogonadism studies.